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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ADAM12
All Species:
5.76
Human Site:
S159
Identified Species:
12.67
UniProt:
O43184
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43184
NP_003465.3
909
99542
S159
Y
V
L
E
P
M
K
S
A
T
N
R
Y
K
L
Chimpanzee
Pan troglodytes
XP_508106
914
100282
S164
Y
V
L
E
P
M
K
S
A
T
N
R
Y
K
L
Rhesus Macaque
Macaca mulatta
XP_001087980
909
99411
N159
Y
V
L
E
P
M
K
N
A
T
N
R
Y
K
L
Dog
Lupus familis
XP_546274
909
99674
N164
H
L
K
L
P
L
G
N
C
G
F
K
Y
S
K
Cat
Felis silvestris
Mouse
Mus musculus
Q61824
903
98582
N157
Y
S
L
E
P
M
K
N
T
T
D
S
Y
K
L
Rat
Rattus norvegicus
Q9QYV0
816
88034
P158
S
Y
T
L
E
L
G
P
G
D
L
Q
R
P
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507222
856
93750
Y149
E
D
L
Q
S
M
K
Y
V
E
L
Y
L
V
A
Chicken
Gallus gallus
NP_001136322
922
101009
G174
Y
I
L
E
P
L
E
G
A
T
S
E
H
K
I
Frog
Xenopus laevis
O42596
935
104143
K177
Y
L
I
E
P
G
E
K
Y
N
P
N
E
D
Y
Zebra Danio
Brachydanio rerio
XP_001921148
773
83366
H144
K
L
L
P
L
R
A
H
D
N
A
Q
L
I
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999635
1023
111059
E163
Y
Y
I
E
L
L
L
E
A
D
E
Q
H
L
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.3
94.8
43.7
N.A.
80.3
35.5
N.A.
43.3
71.5
28.3
56.7
N.A.
N.A.
N.A.
N.A.
35.8
Protein Similarity:
100
95.9
97.1
59.4
N.A.
88.1
50.3
N.A.
58
82.4
44.4
65.2
N.A.
N.A.
N.A.
N.A.
51.2
P-Site Identity:
100
100
93.3
13.3
N.A.
66.6
6.6
N.A.
20
46.6
20
6.6
N.A.
N.A.
N.A.
N.A.
20
P-Site Similarity:
100
100
100
46.6
N.A.
80
20
N.A.
26.6
86.6
40
20
N.A.
N.A.
N.A.
N.A.
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
10
0
46
0
10
0
0
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% C
% Asp:
0
10
0
0
0
0
0
0
10
19
10
0
0
10
0
% D
% Glu:
10
0
0
64
10
0
19
10
0
10
10
10
10
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% F
% Gly:
0
0
0
0
0
10
19
10
10
10
0
0
0
0
0
% G
% His:
10
0
0
0
0
0
0
10
0
0
0
0
19
0
0
% H
% Ile:
0
10
19
0
0
0
0
0
0
0
0
0
0
10
10
% I
% Lys:
10
0
10
0
0
0
46
10
0
0
0
10
0
46
10
% K
% Leu:
0
28
64
19
19
37
10
0
0
0
19
0
19
10
46
% L
% Met:
0
0
0
0
0
46
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
28
0
19
28
10
0
0
0
% N
% Pro:
0
0
0
10
64
0
0
10
0
0
10
0
0
10
0
% P
% Gln:
0
0
0
10
0
0
0
0
0
0
0
28
0
0
0
% Q
% Arg:
0
0
0
0
0
10
0
0
0
0
0
28
10
0
0
% R
% Ser:
10
10
0
0
10
0
0
19
0
0
10
10
0
10
10
% S
% Thr:
0
0
10
0
0
0
0
0
10
46
0
0
0
0
0
% T
% Val:
0
28
0
0
0
0
0
0
10
0
0
0
0
10
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
64
19
0
0
0
0
0
10
10
0
0
10
46
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _